The Scientist: Molecule found in Huntington’s patients kills cancer cells

| Posted in Brain Disease, Brain Education, Brain Research

Small interfering RNAs (siRNAs) responsible for brain damage in Huntington’s patients are also toxic to cancer cells, according to researchers at Northwestern University. The findings, published yesterday (February 12) in EMBO Reports, could provide a novel approach to cancer therapy. Huntington’s is caused by trinucleotide repeat (TNR) expansions, excessive repeats of RNA sequences in the huntingtin gene, which generate proteins and RNA that gradually damage brain cells. Of these, small interfering RNAs (siRNAs) are also toxic to cancer cells, the researchers report. (February 13, 2018)

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