Spectrum: Gene expression ‘barcode’ maps cells in brain tissue

| Posted in Brain Education, Brain Health, Brain Research

A new technique transforms the previous broad-brush picture of a brain region into a pointillist masterpiece of neuronal subpopulations associated with specific activities. The method, called multiplexed error-robust fluorescence in situ hybridization (MERFISH), detects gene expression in intact tissue1. It uses DNA probes to tag individual RNA molecules inside brain cells with a fluorescent dye. The glowing molecules together form a ‘barcode’ that defines each RNA. (November 7, 2018)

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