Brain Disease

MedWire: Community living linked to improved cognition in schizophrenia

Chronically institutionalized patients with schizophrenia show cognitive improvement when they move to community-based living, Japanese research shows. “These results suggest that care settings affect the course of cognition, and addressing these conditions may lead to a certain degree of cognitive improvement even among schizophrenia patients who have been chronically institutionalized”, write Takahiro Nemoto (Toho University […]

Science Codex: First brain images of African infants enable research into cognitive effects of nutrition

Brain activity of babies in developing countries could be monitored from birth to reveal the first signs of cognitive dysfunction, using a new technique piloted by a London-based university collaboration. The cognitive function of infants can be visualised and tracked more quickly, more accurately and more cheaply using the method, called functional near infra-red spectroscopy […]

Los Angeles Times: Narrowed Carotid Artery Also A Risk For Slow Thinking, Not Just Stroke

But research to be presented next week at the American Academy of Neurology’s 66th annual meeting suggests that well before stroke occurs, patients found to have carotid stenosis may already suffer ill effects from carotid artery narrowing. A study compared the learning and memory skills of 67 subjects with 50% reduction in the diameter of the carotid […]

News-Medical: New Approach May Help Reduce Use of Antipsychotics and Other Psychiatric Drugs in Dementia Patients

A new approach to handling agitation, aggression and other unwanted behaviors by people with dementia may help reduce the use of antipsychotics and other psychiatric drugs in this population, and make life easier for them and their caregivers, a team of experts says. Publishing their recommendations under the easy-to-remember acronym of “DICE”, the panel of specialists in […]

Medical News Today: New approach to Alzheimer’s treatment found in novel class of compounds

Led by Dr. Scott Small, director of the Alzheimer’s Disease Center at Columbia University Medical Center in New York, the team used computer-based virtual screening to identify the new “chaperone” compounds. They say these compounds can greatly increase retromer levels and decrease amyloid-beta levels in hippocampal neurons, and Dr. Small says their approach “may prove […]

Scientific Computing: Alzheimer’s-Cancer Link found using Biomedical Data, Supercomputing

Lead investigator Stephen Wong, a medical researcher and bioengineer with HMRI, said his study showed a new link between Alzheimer’s disease, the most prevalent form of neurodegenerative disease, and glioblastoma multiform (GBM), the most aggressive form of brain cancer. “This is the first time people have found that, at the molecular mechanism level, there are […]

HPC Wire: Brain Cancer, Alzheimer’s Share Cellular Process

Using the advanced computational resources at the Texas Advanced Computing Center (TACC) at The University of Texas at Austin, researchers uncovered a link between Alzheimer’s disease and cancer that may pave the way for better treatment options and new medicines. The two afflictions share a pathway in gene transcription, a process essential for cell reproduction […]

Red Orbit: Sleep Disorder Linked To Brain Disease

Researchers at the University of Toronto say a sleep disorder that causes people to act out their dreams is the best current predictor of brain diseases like Parkinson’s and Alzheimer’s. “Rapid-eye-movement sleep behavior disorder (RBD) is not just a precursor but also a critical warning sign of neurodegeneration that can lead to brain disease,” says […]

HealthDay: Certain Type of Brain Malformation May Be Best Left Alone

People with abnormal connections between arteries and veins in the brain may be less likely to suffer a stroke or die if they don’t undergo any procedures to correct the problem, new research suggests. The study included 204 patients in Scotland who had these types of abnormal connections — called “brain arteriovenous malformations” or bAVMs […]

Weill Cornell: “Chaperone” Compounds Offer New Approach to Alzheimer’s Treatment

A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer’s disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where […]