Medical News Today: New approach to Alzheimer’s treatment found in novel class of compounds

Led by Dr. Scott Small, director of the Alzheimer’s Disease Center at Columbia University Medical Center in New York, the team used computer-based virtual screening to identify the new “chaperone” compounds. They say these compounds can greatly increase retromer levels and decrease amyloid-beta levels in hippocampal neurons, and Dr. Small says their approach “may prove […]

Scientific Computing: Alzheimer’s-Cancer Link found using Biomedical Data, Supercomputing

Lead investigator Stephen Wong, a medical researcher and bioengineer with HMRI, said his study showed a new link between Alzheimer’s disease, the most prevalent form of neurodegenerative disease, and glioblastoma multiform (GBM), the most aggressive form of brain cancer. “This is the first time people have found that, at the molecular mechanism level, there are […]

HPC Wire: Brain Cancer, Alzheimer’s Share Cellular Process

Using the advanced computational resources at the Texas Advanced Computing Center (TACC) at The University of Texas at Austin, researchers uncovered a link between Alzheimer’s disease and cancer that may pave the way for better treatment options and new medicines. The two afflictions share a pathway in gene transcription, a process essential for cell reproduction […]

Daily Beast: Study Says Half of Jailed NYC Teens Have History of Brain Injury

The incidence of traumatic brain injury (TBI) and concussion in America’s youth is likely underreported. Still today, some children are told to “walk off” a blow to the head or shake off having had their “bell rung.” Though the nation’s athletic community is more cognizant of these issues than ever before, brain injuries require improved […]

Red Orbit: Sleep Disorder Linked To Brain Disease

Researchers at the University of Toronto say a sleep disorder that causes people to act out their dreams is the best current predictor of brain diseases like Parkinson’s and Alzheimer’s. “Rapid-eye-movement sleep behavior disorder (RBD) is not just a precursor but also a critical warning sign of neurodegeneration that can lead to brain disease,” says […]

HealthDay: Certain Type of Brain Malformation May Be Best Left Alone

People with abnormal connections between arteries and veins in the brain may be less likely to suffer a stroke or die if they don’t undergo any procedures to correct the problem, new research suggests. The study included 204 patients in Scotland who had these types of abnormal connections — called “brain arteriovenous malformations” or bAVMs […]

Weill Cornell: “Chaperone” Compounds Offer New Approach to Alzheimer’s Treatment

A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer’s disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where […]

Family Practice News: Asymptomatic Stenosis Could Cause Cognitive Impairment

Asymptomatic carotid stenosis may not be asymptomatic after all. Patients with a stenosis of 50% or more performed significantly worse on cognitive tests than did those without. Those cognitive issues were very likely clinically significant as well, according to a study to be presented April 30 at the annual meeting of the American Academy of […]

HealthLineNews: Is ‘Sluggish Cognitive Tempo’ a New Disorder or an Extension of ADHD?

More than six million children in the U.S. have been diagnosed with attention deficit hyperactivity disorder (ADHD), and that number has been increasing steadily in recent years. Now, some mental health researchers are pushing for acceptance of a second attention disorder, raising concerns about overdiagnosis and overtreatment of these types of conditions. Known as sluggish […]